Bio-equivalence study of two oral doxycycline formulations (doxycycline kela 75%® and mebcodox 75%®) in broiler Chickens
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منابع مشابه
Bioequivalence Study of Two Oral Doxycycline Formulations (Doxysol® and Doxymed®) in Healthy Broiler Chickens
Aims: The present study was designed to assess the comparative bio-equivalence of Doxysol® and Doxymed® in healthy broiler chickens after oral administration of both products in a dose of 20 mg doxycycline/kg.b.wt. Materials and Methods: Twenty broiler chickens were divided into two groups. The first group was designed to study the pharmacokinetics of Doxysol, while the 2nd group was designed t...
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A bioequivalence and pharmacokinetics profiles of two doxycycline powder formulations (Providox and Doxyvet 0-50 S ) were compared in 24 healthy chickens following administration of a single oral dose ® (20 mg/kg bw). Serial blood samples were drawn at 10 points after administration to determine doxycycline concentrations in chicken plasma by HPLC/UV. the pharmacokinetics parameters; area under...
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Tylosin, a drug mainly used in veterinary medicine, belongs to the macrolide group of antibiotics. In this study the bioequivalence and differences in pharmacokinetics of solution and powdered tylosin formulations were established. The following recommended by EMEA parameters: Cmax, Tmax, AUC were determined. All the investigations were carried out in the populations of 74 broilers chickens. Th...
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Probiotics and antibiotics are widely used in poultry and may alter drug bioavailability by affecting the expression of intestinal ATP-binding cassette (ABC) efflux transporters. Therefore the aim of the present investigation was to evaluate the effect of Lactobacilli probiotics, administered alone or in combination with doxycycline, on the expression of ABCB1 (gene, encoding P-glycoprotein), A...
متن کاملComparative Bio-equivalence Study of Dolistin and Colidox in Chickens
The comparative bio-equivalence of Dolistin and Colidox at a dose rate of 10 mg doxycycline/kg ® ® b. wt. was studied in 48 clinically normal broiler chickens. After oral administration, plasma levels of doxycyline peaked after 2 hours post-dosing without significant differences between the two products and it could be detected therapeutically and exceeded the minimum inhibitory concentration (...
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ژورنال
عنوان ژورنال: International Journal of Pharmacology and Toxicology
سال: 2020
ISSN: 2310-2985
DOI: 10.14419/ijpt.v8i1.30477